Ovarian exhaustion, lack of ovarian reserve (menopause) – does it always lead to the oocyte donation?
Is there hope to obtain your “own” cells and give birth to a genetically healthy child? There is always a chance! And we will provide you with details in this article.
The biggest reproduction problem is a problem of low ovarian reserve and its complete loss. People inevitably face this problem with age, although it is not that uncommon even among young people (premature ovarian exhaustion), often after surgical treatment for pelvic problems.
While almost everything related to other reproduction problems can be solved thanks to the high tech medical care, the reduction, exhaustion or lack of ovarian reserve (menopause) is like an unassailable fortress for reproductive endocrinologists from around the world. Nowadays, the only way to achieve pregnancy in this kind situation is to use donor’s eggs (oocytes), taken from a woman with good ovarian reserve. Afterwards the high tech medical care methods are applied and the woman with an ovarian reserve problem can get pregnant and give birth! In most countries, the ethical side of the procedure is no longer an issue. It is fairly obvious that this is the fastest way to achieve pregnancy.
A solution has been recently found in Japan.
Professor, MD Kazuhiro Kawamura figured out a way to activate “silent” ovaries. The activation takes place outside the human body, in the IVF laboratory, where they remove the natural genetic block from the cells. However, a laparoscopic operation on the patient’s ovaries is an unpleasant but necessary step to extract ovarian tissue, which will be activated later with the use of specialized equipment.
The activated ovarian tissue is put back into the patient’s body, and where it proceeds to develop on its own, producing follicles. After some time, the patient’s periods come back for 1-3 cycles. If during this timeframe the ovarian stimulation is carried out, then the eggs suitable for fertilization can be produced. This method resulted into the birth of several perfectly healthy children. Professor Kawamura called it IVA.
Some of the largest and most influential IVF clinics seek to obtain this treatment method. The most determined patients travel to Japan to get a chance to try IVA.
On June 1, 2019, Professor Kazuhiro Kawamura visited Altravita together with his colleague and co-author from the USA, professor Aaron JW Hsueh. After a week of thorough examination and meticulous of Altravita with other medical institutions in Russia, including some of the leading state-funded research centers, AltraVita was selected to perform IVA treatment in Russian Federation. The professors emphasized that there are not many clinics like AltraVita in the modern world of medical services, because we have vast experience in complying with strict certification standards. Our clinic remains the only one in Russia to voluntarily go through the certification by the American system of quality control of medical institutions CAP - College of American Pathologists.
Popular IVF programs
Frozen embryo transfer is considerably less complicated than the classic IVF program. It consists of three stages: getting the endometrium ready, transferring the embryos and maintaining the luteal phase.
Frozen embryo transfer is one of ART techniques.
Basically, it is an in-vitro fertilization program minus the stimulation stage. This technique is advisable when the IVF protocol for some reason was unsuccessful. By preserving the embryos, the parents receive a kind of moral support boost, because even if the first try fails, there is always a second chance. Besides, it will be easier and a lot cheaper.
Many couples choose to tray frozen embryo transfer program after a successful IVF attempt to have a second baby.
The end result of this technique depends on various factors which include:
Some scientists claim that the high dosage of hormones that women are injected with during the stimulation can alter the qualities of their endometrium and may have negative effect on its ability to accept and nourish the embryo.
If the patients use the frozen embryo transfer program, there is no need to do take hormones in such high doses, which makes this program closer to the natural way of things. Consequently, the pregnancy is likely to go more smoothly from the physiological point of view.
Is it necessary for the father to do a medical check-up with this protocol? Yes, it is. Even though he is not actually involved in the process of the transfer and has done the required tests during the first cycle, the frozen embryo transfer recommendations list does contain several obligatory examinations. As for the mother, out of all the usual hormone level exams she only has to do the progesterone blood test, because this hormone is prescribed to ensure a healthy pregnancy.
Sometimes, though fairly rarely, the usual superovulation stimulation protocol is still required to prepare the endometrium for the transfer. This happens when there is no natural ovulation and if the standard preparatory procedures yielded no results.
Regardless of their education level, many people still consider embryo cryopreservation a dangerous procedure that has the potential to harm their future baby. Sometimes, it may be hard for the parents to understand this process. These couples would rather dispose of their spare embryos, which is completely unnecessary and unfounded, just because they are afraid to freeze it.
However, it is essential to realize the difference between a common freezing and cryopreservation. When you freeze something the usual way, the water in the issues crystalizes under the influence of low temperatures and destroys the cell membranes. Cryopreservation in liquid nitrogen happens at the ultra-low temperature of -196 С°. Under these conditions, the ice simply does not have enough time to form. After they are defrosted, more than a half of all embryos can be successfully implanted into the womb tissue and start developing there. Out of 100 frozen embryos, only 5 or 6 of them are lost. Studies have proved that in those cases the cause of death is not related to cryopreservation, but is normally of genetic origin. Large-scale case studies have also demonstrated, that children born from frozen embryos are not any different from other children in terms of general health and course of development, and the pregnancy is usually less problematic. It might be connected to lower amount emotional stress for the parents.
Frozen embryos can be preserved for a very long time. An additional prove to that is the birth of a girl named Emma in 2017. Her embryo has been cryopreserved for 25 years, since 1992. The only condition is to strictly abide by the rules of cryopreservation and defrosting procedures.
In Altravita we use various ART techniques. Thanks to high-level equipment and the skills of our doctors, we keep our statistic results up to the highest standards. You can get more information about cryopreservation from our gynecologists. Call the clinic using the phone number on our website and make an appointment.
Call the clinic using the phone number on our website and make an appointment.
What is IVF in natural cycle? Ultrasound monitoring of growth of the dominant follicle in the ovary of the patients with preserved ovulation.
With a follicle size of 18 mm, either under the control of an ovulation test, or after the intramuscular injection of an ovulation trigger, a follicle is punctured to obtain an egg. The rest of the IVF program process remains the same.
To increase the effectiveness of IVF, the program includes the study of egg’s spindle apparatus. This procedure is carried out on a special apparatus called Poloscope, which allows to examine the spindle, identify defects that can subsequently lead to the development of chromosomal abnormalities. The usage of this technique can increase the chances of implantation and pregnancy and minimize the risk of miscarriage and the birth of a sick child. The rest of the IVF program process remains the same.