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IVF after 40 years

Pregnancy after 40 is a fairly rare occurrence even if you try to conceive naturally. IVF can be a possible solution to this problem for women over 40.

IVF in natural cycle
123 500 RUR
IVF with fresh donor eggs
325 160 RUR
Soft IVF – minimal stimulation
130 372 RUR
Surrogacy program (basic)
2 893 880 RUR

IVF after 40 years

Pregnancy after 40 years old is a fairly rare occurrence even if you try to conceive naturally. IVF can be a possible solution to this problem for women over 40.

The ability to get pregnant, gestate and give birth to a child is determined by the age of woman planning to become a mother.

The pace of modern life involving women’s active social and professional position leads them to delay pregnancy until 35-40 years. Education and career growth come to the fore. Sooner or later women decide to expand the family and start to seek a help from fertility specialists. The fertility specialists advise them to undergo in-vitro fertilization (IVF) procedure.

How to get pregnant over 40?

For a woman after 40 years a possibility of the natural conception and normal pregnancy decreases year after year. Most women who are interested in whether it is possible to get pregnant naturally at 45 years receive a negative answer from their doctor. This is primarily due to the natural decrease of the functional activity of the sex glands and organs of the reproductive system. Nowadays there is an opportunity to prolong a reproductive period due to the development of medicine and the pharmacological industry. Sex hormone stimulating drugs have been created; there are drugs to replace them. Doctors incorporate the latest scientific achievements, research and high-quality equipment. So won’t it really help to get pregnant to those who want to have a baby so much?

Modern ART and IVF come to help patients over 40. Such methods are actively used in AltraVita center. The ovarian reserve assessment is required to determine a possibility of getting pregnant with own eggs to woman over 40.

For this reason the following options are used:

  • determination of AMH (anti mullerian hormone) - allows you to predict the chances of conception, although it does not affect fertility itself and decreases with age;
  • FSH (follicle-stimulating hormone) - the ovarian reserve means sufficient if there is a value of 10 mIU / ml and below;
  • antral follicles - are counted during ultrasound examination.

At this age IVF is often performed in natural cycle, because a large number of eggs cannot be obtained during a stimulation. Follicular tissue does not give a sufficient response to the stimulation. In addition, if patient has a reduced ovarian reserve, this can lead to a complete depletion of the ovaries. Then pregnancy will be possible only with the use of donor egg, and many women are totally against it.

Although, the embryo obtained in the result of fertilization of donor egg with husband’s sperm, has a half of the loved one’s genotype and woman may feel herself a mother when she bears this child under her heart. The important thing is that the donor is carefully examined and does not have the hereditary diseases and this means that the child will be healthy.


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Natural pregnancy after 40 years

A woman's fertility is highest between the ages of 18 and 29, when most of the menstrual cycles are ovulatory. That is, almost every month the ovum ripens in the ovaries and, when favorable conditions are created, conception is possible. With age, the number of ovulatory cycles decreases significantly, and the chances of getting pregnant fall.

Unfortunately, the probability of a natural pregnancy is not too high. By the age of 40, it does not exceed 10-15%. At 50, the odds are close to zero. Although world history knows many cases when women became pregnant and gave birth to children at 50, and even at 60, these are only exceptions to the rules. For an average woman, conceiving after 40 years without resorting to medical care is almost impossible.

In addition, with age, the risk of developing chromosomal abnormalities, various birth defects, for example, Down syndrome, cerebral palsy. According to world studies, if women aged twenty-nine years of age and older have birth defects in approximately 4-6% of cases, then after forty, they appear in 9%.

What to do, how to deal with this problem? In such cases, modern ART will come to the rescue. In particular, good reviews of IVF at this age indicate that it is quite possible to achieve pregnancy in this way.

Factors Affecting Pregnancy

Unfortunately, in addition to decreasing the number of ovulatory cycles with age, health problems may arise that affect, if not conception, then pregnancy. That is why doctors recommend not delaying the birth of a child. But if this still happened, first you need to find out whether a woman can become pregnant and bear a baby.

The possibility of a natural pregnancy depends on many factors:

  • the presence or absence of somatic, endocrine and infectious pathologies;
  • individual characteristics of the woman's body;
  • the rate of development of involute processes leading to the extinction of the functional activity of the reproductive system.

If a woman wants to become pregnant, the specialists of our clinic will prescribe an objective study, the purpose of which is to find out the criteria that affect the possibility of fertilization and the subsequent normal course of pregnancy and childbirth.

Diagnostic tests performed at AltraVita Clinic include:


  • Hormone tests. Laboratory determination of the level of sex hormones is performed on different days of the cycle, the ovarian reserve of the ovaries is determined.
  • Instrumental research. Hysteroscopy, colposcopy, hysterosalpingography, ultrasound of the pelvic organs and other studies allow us to assess the condition of the reproductive organs. With age, the likelihood of developing gynecological diseases increases. Many of them negatively affect fertility.
  • Assessment of somatic health. A woman needs to pass a coagulogram, blood for sugar and thyroid hormones, ECG, fluorography, ultrasound of the mammary glands and some other studies.

They allow you to determine if there are any contraindications to pregnancy. Then begins preparation for the in vitro fertilization protocol.

Assessment of the general condition of the body is necessary, since during pregnancy, the load on many organs increases: the heart, kidneys, etc. The hormonal background changes, immunity decreases. All this can lead to the development of various complications in the mother and the fetus, then a pregnancy that is so hard may have to be interrupted for medical reasons, which will become not only physical, but also emotional trauma for the patient.

In preparation for IVF after 40 in clinic "AltraVita" may be assigned such examinations as:

  • analyzes of smears from the urethra and vagina for genital infections;
  • blood tests for especially dangerous infections;
  • cytology of a smear from the cervix;
  • clinical blood and urine tests;
  • blood chemistry;
  • examination of doctors of various specialties.

If necessary, the study of a man to diagnose the possible presence of infertility in him is included in the diagnostic process and determining the possibility of a woman becoming pregnant. At a minimum, the spouse must pass a spermogram. Based on its results, the issue of conducting additional diagnostic measures are considering.

The condition of the ejaculate is also important for choosing a program. So, in case of impaired sperm motility, the appearance of pathological forms in the sperm, it may be necessary to conduct morphological selection of the sperm and intracytoplasmic injection (ICSI).

If criteria are found that sharply reduce the possibility of conceiving a baby and the normal course of pregnancy in a woman, the center’s doctors can recommend an IVF program after 40 years.

Natural conception is a matter of chance, which often depends on many factors. Even if you accurately determine the day of ovulation and create all the necessary conditions for fertilization, conception may not occur.

During the IVF protocol, stimulation of ovulation allows you to take several eggs. And if some of them do not fertilize, it remains an opportunity to get a full-fledged embryo for transfer to the uterus.

Another problem for those who decide to become pregnant after 40 years old is the risk of having a sick baby. The likelihood of a newborn having Down syndrome and other pathologies at this age increases sharply. In vitro fertilization, it is possible to select high-quality embryos using PGD. Which not only reduces such risks, but the woman does not lose valuable time, because with age new problems and diseases may appear. And an extra psychological trauma due to failure can also affect a woman's condition.

According to the studies of scientists from the University of Adelaide, who analyzed more than 300 thousand natural births and 3600 in vitro fertilization procedures in age-related patients, interesting data were obtained. It turns out that birth defects in "test-tube babies" appear much less frequently in 3.6% of cases than in naturally conceived children at this age. This figure is even less than that of women in labor over 29 years of age. That is, after forty IVF is not only effective, but also reduces the risk of developing abnormalities in the fetus.

It has been suggested that the drugs used in the protocol have a positive effect. Although an important role is played by the careful selection of planted embryos.

Indeed, in life, many pregnancies are interrupted at such a short time that women do not even notice it. Embryo tissue is excreted with menstrual bleeding. So nature gets rid of embryos with serious pathologies. And with artificial insemination, the highest quality germ cells and embryo for replanting are selected.

IVF options for women over 40

After a comprehensive study, the doctor can determine one of several options for the data of ART and IVF after 40 years:

  • Artificial insemination with the sperm of a husband or donor.
  • IVF in a stimulated cycle. Usually a short protocol is used. An important condition is the presence of a sufficient ovarian reserve.
  • IVF in the natural cycle or with minimal stimulation (with reduced ovarian reserve).
  • IVF with donor oocytes - if receiving your own high-quality germ cells seems unlikely.
  • Sperm injection into the cytoplasm of the egg (ICSI), followed by implantation of the embryo on the mucous membrane of the woman’s uterus. It is quite common and in many cases allows a successful IVF after 40 with its own egg.
  • Surrogacy - if for various reasons IVF at the age of 42 with your egg is impossible, and pregnancy is contraindicated for a woman.

Comprehensive diagnosis data suggest not only an assessment of the fertility of the couple, but also the absence of contraindications to the procedure and pregnancy. The main ones: mental abnormalities, somatic diseases that prevent bearing, genital gland pathology, deformations and abnormalities in the structure of the uterus, a cancerous tumor of any localization. A relative limitation is inflammation and benign masses in the genitals.

The specialists of our clinic try to carry out in vitro fertilization with their own egg, even at the age of 45, if possible. Usually a natural cycle is used with minimal stimulation, which allows to minimize the adverse effect of hormonal drugs on the body.

But problems with age arise not only in women, but also in men. In such cases, IVF with ICSI is used. In the AltraVita clinic, to determine the effectiveness of the protocol and reduce the risk of developing chromosomal abnormalities in the fetus, a technique for determining the spindle is used. Thanks to special equipment, it is possible to visualize the spindle elements and conduct ICSI without risking damage to it.

After successful fertilization, preimplantation genetic diagnosis is prescribed in age-related patients. It eliminates mutations and congenital malformations during IVF after 40, the risk of which increases with the age of the expectant mother. PGD is carried out before the implantation procedure and consists of a biopsy of the embryonic cells at the stage of zygote division (fertilized egg cell). A single blastomere is usually taken for research. The main advantage of this diagnosis is that there is no need for an abortion and high chances of having a healthy baby without genetic abnormalities.

If it is not possible to get a quality egg from the mother, we suggest using a donated egg for fertilization. The results of studies show that the use of donor material in women aged gives very good results. If the usual protocol is successful in 26-30% of cases, this indicator is lower than in young patients, then in IVF with a donor egg, pregnancy occurs in 49% of cases.

It is still not well understood why this type of program gives such high results, but studies by scientists from different countries confirm this, as well as the long-term statistics of our clinic.

That is why our experts advise not to waste time on new attempts, but to use donor material in such cases:

  • if an age patient has difficulty receiving an egg;
  • during the embryological stage, it is not possible to obtain a high-quality embryo.

Altravita Clinic has its own cryobank and a large donor base, from which you can choose the most suitable candidate. Our experts will provide all the necessary information about the donor (eye, hair color, constitution, nationality, education, etc.).

We also have a surrogate mother database, if during the examination it turns out that pregnancy is contraindicated for a woman. All candidates are thoroughly examined, have their own healthy children.

Thanks to the use of the latest approaches in the treatment of infertility and ART, doctors at AltraVita clinic often manage to get positive IVF results after 40 years. Contact our center. With a high probability this will allow you to become pregnant even at a late reproductive age.


Thank you so much, Dr. Vladimir Valentinovich, you are both a wonderful person and an exceptional specialist!!! Thanks to your treatment and unique approach, on April 10 we had our precious little girl. You always knew exactly what to say to cheer us up. Despite all the failures, you never lost hope and kept coming up with new treatment plans until at the long last we finally succeeded.  I thank…
2019-10-15 Read more
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I am ever so grateful to Dr. Asharina, who managed to give me hope on one day becoming a mother again. After a miscarriage with severe complications, all other doctors would only shrug and tell me to try harder and keep waiting.  Dr. Asharina, on the other hand, figured out the problem during the very first visit and prescribed the suitable treatment. Now, we are hoping for positive results.    
2019-10-03 Read more
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I’d like to thank the Altravita management for employing such an amazing doctor like Saida A. Magomedova. She is indeed an outstanding specialist in her field. Dr. Magomedova is calm, patient, polite and, more importantly, very experienced! Even though she doesn’t have that many years of experience, she is highly knowledgeable in the area. Thanks to her skills, me and my husband became parents! Thank…
2019-09-17 Read more
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Dr. Zarema Beckkhanovna, there’s so many thoughts in my head, but it’s still not enough to express how grateful we are to you. Thank you for our Son, please, except our deepest and most sincere gratitude.  Thank you for your smiles, encouraging words, warm hugs before the transfer. Thank you for when the test results came in you told us: “We are going”. And so we went. We have come a long way through…
2019-09-12 Read more
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I first went to see Elena Alexandrovna in June. My spermogram was bad. The doctor said that was because of my hormones level and prescribed a treatment plan. After a month, we could already see positive changes. Although it’s still not perfect, I’m hoping for further improvements. The medicine is expensive, but it really works. It’s obvious that the Doctor know what she is doing. They do tests and…
2019-09-11 Read more
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