PGT allows Altravita specialists to base the choice on the results of genetic tests conducted on the patients’ embryos. PGT increases the chances of a genetically normal embryo being selected, implanting successfully and our patients’ chances of carrying and delivering a healthy baby.
Pre-implantation genetic diagnosis (PGD) refers to genetic profiling of embryos created through IVF prior to the transfer into the patient’s uterus. When screened for a specific genetic disease, PGD test allows selection of embryos free of the disease under consideration.
PGD enables patients with an inheritable condition in their family to avoid passing it on to their children. A specialist may recommend PGD if patients have a family history of a serious genetic disease or previous pregnancies were ended because of a serious genetic condition.
The term preimplantation genetic screening (PGS) is used to denote procedures that do not look for a specific disease but use PGD techniques to identify embryos at risk. PGS involves checking the chromosomes of embryos for common abnormalities. Chromosomal abnormalities are a major cause of the failure of embryos to implant, and of miscarriages. They can also cause conditions such as Down’s syndrome.
PGS can be recommended for:
In a standard IVF treatment, every time a cycle produces more than one embryo, a choice must be made about which embryo will be transferred. That choice is determined by the development and appearance of the embryos.
However, advances in scientific techniques mean PGT gives us another factor on which to base the decision - the genetic health of the embryo.
Popular IVF programs
Frozen embryo transfer is considerably less complicated than the classic IVF program. It consists of three stages: getting the endometrium ready, transferring the embryos and maintaining the luteal phase.
Frozen embryo transfer is one of ART techniques.
Basically, it is an in-vitro fertilization program minus the stimulation stage. This technique is advisable when the IVF protocol for some reason was unsuccessful. By preserving the embryos, the parents receive a kind of moral support boost, because even if the first try fails, there is always a second chance. Besides, it will be easier and a lot cheaper.
Many couples choose to tray frozen embryo transfer program after a successful IVF attempt to have a second baby.
The end result of this technique depends on various factors which include:
Some scientists claim that the high dosage of hormones that women are injected with during the stimulation can alter the qualities of their endometrium and may have negative effect on its ability to accept and nourish the embryo.
If the patients use the frozen embryo transfer program, there is no need to do take hormones in such high doses, which makes this program closer to the natural way of things. Consequently, the pregnancy is likely to go more smoothly from the physiological point of view.
Is it necessary for the father to do a medical check-up with this protocol? Yes, it is. Even though he is not actually involved in the process of the transfer and has done the required tests during the first cycle, the frozen embryo transfer recommendations list does contain several obligatory examinations. As for the mother, out of all the usual hormone level exams she only has to do the progesterone blood test, because this hormone is prescribed to ensure a healthy pregnancy.
Sometimes, though fairly rarely, the usual superovulation stimulation protocol is still required to prepare the endometrium for the transfer. This happens when there is no natural ovulation and if the standard preparatory procedures yielded no results.
Regardless of their education level, many people still consider embryo cryopreservation a dangerous procedure that has the potential to harm their future baby. Sometimes, it may be hard for the parents to understand this process. These couples would rather dispose of their spare embryos, which is completely unnecessary and unfounded, just because they are afraid to freeze it.
However, it is essential to realize the difference between a common freezing and cryopreservation. When you freeze something the usual way, the water in the issues crystalizes under the influence of low temperatures and destroys the cell membranes. Cryopreservation in liquid nitrogen happens at the ultra-low temperature of -196 С°. Under these conditions, the ice simply does not have enough time to form. After they are defrosted, more than a half of all embryos can be successfully implanted into the womb tissue and start developing there. Out of 100 frozen embryos, only 5 or 6 of them are lost. Studies have proved that in those cases the cause of death is not related to cryopreservation, but is normally of genetic origin. Large-scale case studies have also demonstrated, that children born from frozen embryos are not any different from other children in terms of general health and course of development, and the pregnancy is usually less problematic. It might be connected to lower amount emotional stress for the parents.
Frozen embryos can be preserved for a very long time. An additional prove to that is the birth of a girl named Emma in 2017. Her embryo has been cryopreserved for 25 years, since 1992. The only condition is to strictly abide by the rules of cryopreservation and defrosting procedures.
In Altravita we use various ART techniques. Thanks to high-level equipment and the skills of our doctors, we keep our statistic results up to the highest standards. You can get more information about cryopreservation from our gynecologists. Call the clinic using the phone number on our website and make an appointment.
Call the clinic using the phone number on our website and make an appointment.
What is IVF in natural cycle? Ultrasound monitoring of growth of the dominant follicle in the ovary of the patients with preserved ovulation.
With a follicle size of 18 mm, either under the control of an ovulation test, or after the intramuscular injection of an ovulation trigger, a follicle is punctured to obtain an egg. The rest of the IVF program process remains the same.
To increase the effectiveness of IVF, the program includes the study of egg’s spindle apparatus. This procedure is carried out on a special apparatus called Poloscope, which allows to examine the spindle, identify defects that can subsequently lead to the development of chromosomal abnormalities. The usage of this technique can increase the chances of implantation and pregnancy and minimize the risk of miscarriage and the birth of a sick child. The rest of the IVF program process remains the same.